PGD and Infertility
Developed in the early 1990's, preimplantation genetic diagnosis (PGD) is a way for couples to prevent a pregnancy affected by a genetic condition or chromosomal disorder. There are various types of PGD available, depending on the needs of the individual couple. This form of genetic testing is performed on eggs or embryos during an in vitro fertilization (IVF) cycle. The eggs or embryos that have been analyzed and are found to be normal are transferred into the woman's uterus, where, hopefully, they will implant and result in the birth of a healthy child.
Currently, we are able to perform PGD for many genetic conditions including single gene disorders and chromosomal abnormalities. At the Institute for Human Reproduction, we have been offering PGD since it became available in 1990.
How can PGD help me?
PGD can significantly reduce the chances for your baby to be affected with a specific genetic condition or chromosomal abnormality. We are able to test for many different diseases, including aneuploidy conditions, single gene disorders, and chromosome translocations.
Many couples request PGD for aneuploidy conditions, such as Down syndrome, trisomy 18, trisomy 13 and Turner syndrome. Aneuploidy conditions typically do not run in families. However, up to 60% of early miscarriages are due to aneuploidy conditions, and the risk for aneuploidy increases with a woman's age. The purpose of PGD for aneuploidy is to increase a couple's chance for pregnancy, reduce their risk for miscarriage, and improve their overall chance of bringing home a healthy baby after in vitro fertilization.
Other couples may request PGD for a specific genetic condition running in their family, such as Tay Sachs disease, cystic fibrosis, muscular dystrophy, Fragile X syndrome or spinal muscular atrophy. Our center has extensive experience testing for many single gene disorders, including rare genetic syndromes.